Ph.d.-projekter
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Among various sources of human toxoplasmosis, infection from consuming undercooked meat is an important one, as the meat may contain viable Toxoplasma gondii parasites. Acquired toxoplasmosis is rarely reported in healthy humans because the symptoms are either mild or absent. But toxoplasmosis in immunocompromised individuals like those with HIV, infection can be life-threatening. In pregnant women, infection may lead to abortions or infection may be passed on to the fetus resulting in brain damage or blindness from congenital toxoplasmosis.
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An intracellular perspective of the metabolism of uropathogenic Escherichia coli PhD Student: Sisse Mortensen Extraintestinal pathogenic E. coli (ExPEC) are able to cause infections outside the intestines. Uropathogenic (UPEC) and Avian Pathogenic (APEC) E. coli are two ExPEC variants. They cause infection in the urinary tract system of human (UPEC) and in the salpinx and airways of birds (APEC), respectively. Genetically, these two ExPECs cannot be distinguished from one another. Previous studies have shown that APEC strains are able to infect in vivo models of human urinary tract infection (UTI), suggesting that they may be zoonotic. But no studies have shown that UPEC can infect in adult immonucompetent bird and examined a potential anthrozoonotic potential of UPEC. |
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PhD Student: Audrey Inge Schytz Andersen-Civil Proanthocyanidins (PAC) are specialized plant metabolites, more commonly known as a type of anti-oxidant, and they are part of the larger phytochemical group of polyphenols. Interestingly, several studies have demonstrated important anti-oxidant and anti-inflammatory properties of PAC both in cellular and animal models. |
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Annotation and Transcriptomic Analysis of Bacillus subtilis with Application in Biotechnology PhD Student: Adrian Geissler Enzymes are crucial to biotechnology and consumer goods. These enzymes are produced by micro-organisms, which are also referred to as cell-factories (in contrast to concrete buildings). One such specific cell-factory organism is the bacterium Bacillus subtilis. |
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| Transcriptome profiling of neurodegenerative disorders modelled with IPSCs and computational methods for CRISPR/Cas9 editing
PhD Student: Giulia Corsi |
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PhD Student: Kathryn Louise Perrin, BVetMed, PhD, Dipl ACZM, Dipl ECZM (ZHM), Zoo Veterinarian |
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Transduction in Staphylococcus aureus PhD Student: Ahlam Alsaadi In Staphylococcus aureus is a pathogenic bacterium that able to infect humans and animals. Third of healthy human population carries Staphylococcus aureus in their interior nares, while the rest are intermittent carriers. READ MORE about the project |
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PhD Student: Camilla Jensen You have probably taken penicillin to cure tonsillitis or other bacterial infections - but have you ever wondered how penicillin actually works? Read more about the CIpX Chaperone and Super-resolution imaging |
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PhD Student: Karin Mundbjerg Mink urinary tract disease (MUTD) is a disease complex characterized by stones in the urinary tract and infection in of the urinary bladder and kidneys. The disease often leads to fatal urethral obstruction, especially in males and is a common cause of mortality in growing mink kits. Urinary tract stones in mink are reported to be composed of the mineral struvite which forms in alkaline urine. |
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PhD Student: Kasper Mikkelsen, email: kasper.mikkelsen@sund.ku.dk Staphylococcus aureus is a serious human pathogen with a remarkable ability to adapt to challenging conditions and cause life-threatening infections. The most important class of antimicrobials for the treatment of S. aureus infections is the β-lactams. By the acquisition of the staphylococcal chromosome cassette (SCCmec), some S. aureus isolates have evolved methicillin-resistance (MRSAs) that are resistant to nearly every β-lactam antibiotic, why additional measures are needed to combat this pathogen. READ MORE |
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Decoding the lamination, cytoarchitecture and cellular composition of the entorhinal cortex PhD Student: Tobias Borgtoft Bergmann, email: tobi@sund.ku.dk, The entorhinal cortex, as part of the parahippocampal region, is involved in unique functions related to spatial navigation and consolidating episodic memory. The entorhinal cortex and the entorhinal cells that are responsible for its unique tasks have mainly been investigated by electrophysiological and histological studies. READ MORE |
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| Contracaecum osculatum larvae in Baltic cod (Gadus morhua): Effects on growth and immune response
PhD student: Huria Marnis, e-mail: marnis.huria@sund.ku.dk The eastern Baltic cod has experienced a marked increase in infection caused by third-stage larvae of the nematode Contracaecum osculatum. The cod acts as transport host with the third-stage larvae located in the liver. The PhD project produced three published papers. READ MORE |
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Biofluid proteome profiling of perinatal infectious diseases in preterm neonates PhD student: Tik Muk, e-mail: tik.muk@sund.ku.dk Perinatal infectious diseases, such as chorioamnionitis (CA) and neonatal sepsis, remain a major cause of neonatal morbidity and mortality, especially for the preterm infant population. Read more |
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Gut and systemic immune responses to prenatal inflammation in preterm neonates PhD student: Shuqiang Ren, e-mail: shuqiang.ren@sund.ku.dk The immature functions of the organs and immune system of preterm infants predispose them to gut and immune disorders. Growth and developmental delays in preterm neonates may affect various organ systems differently at the term-corrected age. Read more |
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Genomic Epidemiology and Aquatic Reservoirs of the Seventh Pandemic Vibrio cholerae in Tanzania With the currently available scientific knowledge and tools to guide prevention and treatment, every death due to cholera can be avoided. Cholera, however, continues to take a heavy toll in developing countries especially in Sub-Saharan Africa, where it has become recurrent for the past forty years favored by poverty, poor hygiene and the vulnerability of populations living around lakes and those affected by conflicts or natural disasters. |
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| Antimicrobial-induced plasmid-transfer in Escherichia coli
PhD student: Gang Liu, e-mail: gangliu@sund.ku.dk, Antimicrobial resistance (AMR) is a serious threat to human and animal health, and it is projected that by the year 2050 more people will die due to infections with AMR bacteria than cancer, if we do not find ways to prevent development and spread of AMR. |
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Genetic diversity and antimicrobial resistance in commensal Escherichia coli from pigs and broiler chickens Escherichia coli is an important part of the gut flora of all warm-blooded vertebrates. So far research has focused on the few types of E. coli that cause disease, while the large group of harmless, commensal E. coli has been neglected. |
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Fasciolosis in Danish dairy cattle: epidemiology, diagnostics, impact and aspects of control (Fasciolose hos dansk malkekvæg: epidemiologi, diagnostik, betydning og kontrol) |