PhD thesis

Immuno-modulatory Properties of Proanthocyanidins and Implications during Helminth-induced Inflammation in the Gut

PhD Student: Audrey Inge Schytz Andersen-Civil
Thesis defended: 6 September 2021

Proanthocyanidins (PAC) are specialized plant metabolites, more commonly known as a type of anti-oxidant, and they are part of the larger phytochemical group of polyphenols. Interestingly, several studies have demonstrated important anti-oxidant and anti-inflammatory properties of PAC both in cellular and animal models.

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Annotation and Transcriptomic Analysis of Bacillus subtilis with Application in Biotechnology

PhD Student: Adrian Geissler

Thesis defended: 17 September 2021

Enzymes are crucial to biotechnology and consumer goods. These enzymes are produced by micro-organisms, which are also referred to as cell-factories (in contrast to concrete buildings). One such specific cell-factory organism is the bacterium Bacillus subtilis.

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Transcriptome profiling of neurodegenerative disorders modelled with IPSCs and computational methods for CRISPR/Cas9 editing

PhD Student: Giulia Corsi
Thesis defended: 3th September 2021
The primary goal of the project was to better understand the cellular mechanisms related to two neurodegenerative disorders, namely Alzheimer’s disease (AD) and frontotemporal dementia linked to chromosome 3 (FTD3).
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Casualty or carrier? Understanding the pathogenesis of elephant endotheliotropic herpesvirus haemorrhagic-disease in Asian elephants (Elephas maximus)

PhD Student: Kathryn Louise Perrin, BVetMed, PhD, Dipl ACZM, Dipl ECZM (ZHM), Zoo Veterinarian
Thesis defended: 4th June 2021
Elephant endotheliotropic herpesvirus (EEHV) infection is endemic within the worldwide Asian elephant (Elephas maximus) population. An acute and often fatal haemorrhagic syndrome, EEHV-haemorrhagic disease (EEHV-HD), is associated with EEHV infection and is reported to be the most common cause of death of young Asian elephants. READ MORE about the project

Transduction in Staphylococcus aureus

PhD Student: Ahlam Alsaadi
Thesis defended: 18 May 2021

In Staphylococcus aureus is a pathogenic bacterium that able to infect humans and animals. Third of healthy human population carries Staphylococcus aureus in their interior nares, while the rest are intermittent carriers. READ MORE about the project

The ClpX Chaperone and Super-Resolution Imaging – a promising toolbox to explore Staphylococcus aureus cell division and the killing mechanism of β-lactam antibiotics

PhD Student: Camilla Jensen
Thesis defended: 27 April 2021

You have probably taken penicillin to cure tonsillitis or other bacterial infections - but have you ever wondered how penicillin actually works? Read more about the CIpX Chaperone and Super-resolution imaging

Development of new tools for veterinary practice in relation to cystitis and urolithiasis in mink - optimization of prevention and treatment

PhD Student: Karin Mundbjerg
Thesis defended: 9 July 2021

Mink urinary tract disease (MUTD) is a disease complex characterized by stones in the urinary tract and infection in of the urinary bladder and kidneys. The disease often leads to fatal urethral obstruction, especially in males and is a common cause of mortality in growing mink kits. Urinary tract stones in mink are reported to be composed of the mineral struvite which forms in alkaline urine. 
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Intrinsic resistance mechanisms and CRISPR-Cas immunity of the opportunistic pathogen, Staphylococcus aureus

PhD Student: Kasper Mikkelsen, email: kasper.mikkelsen@sund.ku.dk
Thesis defended: 23 April 2021

Staphylococcus aureus is a serious human pathogen with a remarkable ability to adapt to challenging conditions and cause life-threatening infections. The most important class of antimicrobials for the treatment of S. aureus infections is the β-lactams. By the acquisition of the staphylococcal chromosome cassette (SCCmec), some S. aureus isolates have evolved methicillin-resistance (MRSAs) that are resistant to nearly every β-lactam antibiotic, why additional measures are needed to combat this pathogen. READ MORE 

Decoding the lamination, cytoarchitecture and cellular composition of the entorhinal cortex

PhD Student: Tobias Borgtoft Bergmann, email: tobi@sund.ku.dk, 
Thesis defended: 21 April 2021.  

The entorhinal cortex, as part of the parahippocampal region, is involved in unique functions related to spatial navigation and consolidating episodic memory. The entorhinal cortex and the entorhinal cells that are responsible for its unique tasks have mainly been investigated by electrophysiological and histological studies. READ MORE

Contracaecum osculatum larvae in Baltic cod (Gadus morhua): Effects on growth and immune response

PhD student: Huria Marnis, e-mail:  marnis.huria@sund.ku.dk

The eastern Baltic cod has experienced a marked increase in infection caused by third-stage larvae of the nematode Contracaecum osculatum. The cod acts as transport host with the third-stage larvae located in the liver. The PhD project produced three published papers. READ MORE

Biofluid proteome profiling of perinatal infectious diseases in preterm neonates

PhD student: Tik Muk, e-mail: tik.muk@sund.ku.dk
Department of Veterinary and Animal Sciences, Comparative Pediatrics and Nutrition
Thesis defended: February 2020

Perinatal infectious diseases, such as chorioamnionitis (CA) and neonatal sepsis, remain a major cause of neonatal morbidity and mortality, especially for the preterm infant population. Read more

Gut and systemic immune responses to prenatal inflammation in preterm neonates

PhD student: Shuqiang Ren, e-mail: shuqiang.ren@sund.ku.dk
Department of Veterinary and Animal Sciences, Comparative Pediatrics and Nutrition
Status: Defended February 2020

The immature functions of the organs and immune system of preterm infants predispose them to gut and immune disorders. Growth and developmental delays in preterm neonates may affect various organ systems differently at the term-corrected age. Read more

Genomic Epidemiology and Aquatic Reservoirs of the Seventh Pandemic Vibrio cholerae in Tanzania
PhD student: Yaovi Mahuton Gildas Hounmanou, e-mail: gil@sund.ku.dk
Department of Veterinary and Animal Sciences, Section of Food Safety and Zoonosis
Status: Defended 19 December 2019

With the currently available scientific knowledge and tools to guide prevention and treatment, every death due to cholera can be avoided. Cholera, however, continues to take a heavy toll in developing countries especially in Sub-Saharan Africa, where it has become recurrent for the past forty years favored by poverty, poor hygiene and the vulnerability of populations living around lakes and those affected by conflicts or natural disasters.
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Antimicrobial-induced plasmid-transfer in Escherichia coli

PhD student: Gang Liu, e-mail: gangliu@sund.ku.dk,
Department of Veterinary and Animal Sciences, Section for Veterinary Clinical Microbiology
Status: Defended 18 December 2019

Antimicrobial resistance (AMR) is a serious threat to human and animal health, and it is projected that by the year 2050 more people will die due to infections with AMR bacteria than cancer, if we do not find ways to prevent development and spread of AMR.
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Genetic diversity and antimicrobial resistance in commensal Escherichia coli from pigs and broiler chickens
PhD student: Shahana Ahmed, e-mail: shahana@sund.ku.dk
Department of Veterinary and Animal Sciences, Section of Veterinary Clinical Microbiology
Status: Defended 28 November 2019

Escherichia coli is an important part of the gut flora of all warm-blooded vertebrates. So far research has focused on the few types of E. coli that cause disease, while the large group of harmless, commensal E. coli has been neglected.
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Fasciolosis in Danish dairy cattle: epidemiology, diagnostics, impact and aspects of control (Fasciolose hos dansk malkekvæg: epidemiologi, diagnostik, betydning og kontrol)
Ph.d.-student: Nao Takeuchi-Storm, e-mail: nao@sund.ku.dk
Status: Forsvaret 22. marts 2019

Den store leverikte, på latin Fasciola hepatica, er en parasitisk fladorm (ikte), som inficerer drøvtyggere og flere andre pattedyr, inklusive mennesket.
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